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Literature summary for 1.14.13.8 extracted from

  • Novick, R.M.; Elfarra, A.A.
    Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes (2008), Drug Metab. Dispos., 36, 2468-2474.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics for kidney and liver enzymes, overview Rattus norvegicus
0.01
-
Methimazole pH 7.6, 37°C, purified FMO3 from liver Rattus norvegicus
0.04
-
Methimazole pH 7.6, 37°C, purified FMO3 from kidney Rattus norvegicus
0.31
-
seleno-L-methionine pH 7.6, 37°C, purified FMO3 from liver Rattus norvegicus
0.35
-
seleno-L-methionine pH 7.6, 37°C, purified FMO3 from kidney Rattus norvegicus
2.8
-
L-methionine pH 7.6, 37°C, purified FMO3 from kidney Rattus norvegicus
3.4
-
L-methionine pH 7.6, 37°C, purified FMO3 from liver Rattus norvegicus
4.3
-
S-allyl-L-cysteine pH 7.6, 37°C, purified FMO3 from kidney Rattus norvegicus
5.9
-
S-allyl-L-cysteine pH 7.6, 37°C, purified FMO3 from liver Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
x * 56000, kidney enzyme, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q9EQ76 male sprague-dawley rats
-

Purification (Commentary)

Purification (Comment) Organism
native FMO3 130fold from kidney microsomes Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.15
-
purified enzyme, substrate L-methionine Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine + NADPH + H+ + O2 stereochemistry, overview Rattus norvegicus methionine S-oxide + NADP+ + H2O formation of 80% D-isomer ?
methimazole + NADPH + H+ + O2 i.e. N-methyl-2-mercaptoimidazole Rattus norvegicus methimazole S-oxide + NADP+ + H2O
-
?
S-allyl-L-cysteine + NADPH + H+ + O2 stereochemmistry, overview Rattus norvegicus ? + NADP+ + H2O
-
?
seleno-L-methionine + NADPH + H+ + O2
-
Rattus norvegicus seleno-L-methionine Se-oxide + NADP+ + H2O
-
?

Subunits

Subunits Comment Organism
? x * 56000, kidney enzyme, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
FMO3
-
Rattus norvegicus
Met S-oxidase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD consensus binding sequence is Gly-Xaa-Gly-Xaa-Xaa-Gly Rattus norvegicus
NADPH consensus binding sequence is Gly-Leu-Gly-Asn-Ser-Gly Rattus norvegicus

General Information

General Information Comment Organism
physiological function FMO3 plays an important role in kidney metabolism of xenobiotics containing sulfur and selenium atoms Rattus norvegicus