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Literature summary for 1.14.13.8 extracted from

  • Borbas, T.; Benko, B.; Dalmadi, B.; Szabo, I.; Tihanyi, K.
    Insulin in flavin-containing monooxygenase regulation. Flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes (2006), Eur. J. Pharm. Sci., 28, 51-58.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information insulin itself has no effect on FMO1 activity in non-diabetic animals Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme plays an important role in drug metabolism, insulin itself has no effect on FMO1 activity in non-diabetic animals, but hepatic isozyme FMO1 and intestinal CYP3A activity are correlated with average blood glucose concentration in untreated diabetic rats, and insulin reduces CYP3A activity, thus also regulates FMO1 indirectly ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
healthy and streptozotocin-induced diabetic rats
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzydamine + NADPH + O2
-
Rattus norvegicus benzydamine N-oxide + NADP+ + H2O
-
?
additional information the enzyme plays an important role in drug metabolism, insulin itself has no effect on FMO1 activity in non-diabetic animals, but hepatic isozyme FMO1 and intestinal CYP3A activity are correlated with average blood glucose concentration in untreated diabetic rats, and insulin reduces CYP3A activity, thus also regulates FMO1 indirectly Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
FMO
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Rattus norvegicus
NADPH
-
Rattus norvegicus