Inhibitors | Comment | Organism | Structure |
---|---|---|---|
propranolol | competitive, reaction with lidocaine or bupivacaine | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.143 | - |
lidocaine | pH 8.0, 25°C | Sus scrofa | |
0.21 | - |
propranolol | pH 8.0, 25°C | Sus scrofa | |
0.408 | - |
bupivacaine | pH 8.0, 25°C | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.122 | - |
activity with bupivacaine | Sus scrofa |
0.141 | - |
activity with propranolol | Sus scrofa |
0.176 | - |
activity with lidocaine | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bupivacaine + NADPH + O2 | - |
Sus scrofa | bupivacaine-oxide + NADP+ | - |
? | |
lidocaine + NADPH + O2 | - |
Sus scrofa | lidocaine-oxide + NADP+ | - |
? | |
propranolol + NADPH + O2 | - |
Sus scrofa | propranolol-hydroxylamine + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Sus scrofa | |
NADPH | - |
Sus scrofa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
propranolol | pH 8.0, 25°C, inhibition of reaction with lidocaine | Sus scrofa |