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Literature summary for 1.14.13.8 extracted from

  • Schlenk, D.; Li-Schlenk, R.
    Characterization of liver flavin-containing monooxygenase of the dogfish shark (Squalus acanthias) and partial purification of liver flavin-containing monooxygenase of the silky shark (Carcharhinus falciformis) (1994), Comp. Biochem. Physiol. B, 109, 655-664.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Methimazole not competitive; oxidation of dimethylaniline Squalus acanthias
thiobenzamide oxidation of dimethylaniline, competitive Squalus acanthias
trimethylamine 1 mM, oxidation of dimethylaniline, competitive Squalus acanthias

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.044
-
N,N-Dimethylaniline
-
Squalus acanthias

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Squalus acanthias
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
Western blot, anti-FMO 2 antisera Squalus acanthias
50000
-
Western blot, anti-FMO 2 antisera Carcharhinus falciformis

Organism

Organism UniProt Comment Textmining
Carcharhinus falciformis
-
silky shark
-
Squalus acanthias
-
dogfish shark
-

Purification (Commentary)

Purification (Comment) Organism
partial Carcharhinus falciformis

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methimazole + NADPH + O2
-
Squalus acanthias N-methylmethimidazole-2-sulfinic acid + NADP+ + H2O
-
?
N,N-dimethylaniline + NADPH + H+ + O2
-
Squalus acanthias N,N-dimethylaniline N-oxide + NADP+ + H2O
-
r
N,N-dimethylaniline + NADPH + O2
-
Squalus acanthias N,N-dimethylaniline N-oxide + NADP+ + H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
-
Squalus acanthias

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
15 45 15°C, 76% loss of activity, 45°C 99% loss of activity Squalus acanthias

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.6
-
-
Squalus acanthias