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Literature summary for 1.14.13.148 extracted from

  • Klick, D.E.; Shadley, J.D.; Hines, R.N.
    Differential regulation of human hepatic flavin containing monooxygenase 3 (FMO3) by CCAAT/enhancer-binding protein beta (C/EBPbeta) liver inhibitory and liver activating proteins (2008), Biochem. Pharmacol., 76, 268-278.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Homo sapiens
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additional information FMO3 is not expressed in HepG2 cells Homo sapiens
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Synonyms

Synonyms Comment Organism
flavin containing monooxygenase 3
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Homo sapiens
FMO3
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens no changes in relative FMO3 mRNA levels are observed with 50 nM trichostatin A additional information
Homo sapiens 5-aza-2'-deoxycytidine at 0.001 mM and 0.0025 mM results in 6.6fold and 9.2fold increases in FMO3 mRNA levels, respectively. HNF4alpha transient expression results in a 3.1fold increase in FMO3 mRNA levels. Co-transfection of HepG2 cells with the CCAAT/enhancer-binding protein beta expression vector and the pRNH694 reporter construct results in a dose-dependent increase in FMO3 promoter activity with a maximal 2fold increase using 0.001 mg of expression up