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Literature summary for 1.14.11.17 extracted from

  • McCusker, K.; Klinman, J.
    Facile synthesis of 1,1-[2H2]-2-methylaminoethane-1-sulfonic acid as a substrate for taurine a ketoglutarate dioxygenase (TauD) (2009), Tetrahedron Lett., 50, 611-613.
No PubMed abstract available

Application

Application Comment Organism
biotechnology model system for non-heme iron oxygenases Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0051
-
N-methyltaurine deuterated substrate Escherichia coli
0.0056
-
O2 deuterated substrate 2-methyltaurine Escherichia coli
0.0194
-
taurine
-
Escherichia coli
0.041
-
O2 commercially available substrate 2-methyltaurine Escherichia coli
0.041
-
O2 substrate taurine Escherichia coli
0.046
-
O2 substrate 2-methyltaurine Escherichia coli
0.048
-
N-methyltaurine commercially available substrate Escherichia coli
0.054
-
N-methyltaurine
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-methyltaurine + 2-oxoglutarate + O2
-
Escherichia coli CO2 + succinate + sulfite + methylaminoacetaldehyde
-
?
taurine + 2-oxoglutarate + O2
-
Escherichia coli CO2 + succinate + sulfite + aminoacetaldehyde
-
?

Synonyms

Synonyms Comment Organism
TauD
-
Escherichia coli
taurine alpha ketoglutarate dioxygenase
-
Escherichia coli

General Information

General Information Comment Organism
physiological function important in antibiotic biosynthesis, oxygen sensing, DNA repair, biodegradation of anthropogenic compounds Escherichia coli

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.00000001
-
O2 substrate 2-methyltaurine Escherichia coli
0.000000011
-
O2 deuterated substrate 2-methyltaurine Escherichia coli
0.000000012
-
O2 commercially available substrate 2-methyltaurine Escherichia coli
0.000000012
-
O2 sustrate taurine Escherichia coli
0.000000025
-
taurine
-
Escherichia coli