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Literature summary for 1.14.11.17 extracted from

  • Grzyska, P.K.; Hausinger, R.P.
    Cr(II) reactivity of taurine/alpha-ketoglutarate dioxygenase (2007), Inorg. Chem., 46, 10087-10092.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
Y73F active, but mutant is incapable of formation of a Cr(III)-semiquinone chromophore Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Cr2+ Cr(II) replaces Fe2+ and binds stoichiometrically with 2-oxoglutarate to the Fe(II)/2-oxoglutarate binding site of the protein, with additional Cr(II) used to generate a chromophore attributed to a Cr(III)-semiquinone in a small percentage of the sample. Formation of the semiquinone requires the dihydroxyphenylalanine quinone form of Y73, generated by intracellular self-hydroxylation Escherichia coli
Fe2+
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-