Any feedback?
Literature summary for 1.13.12.7 extracted from
- Coenzyme A affects firefly luciferase luminescence because it acts as a substrate and not as an allosteric effector (2005), FEBS J., 272, 5206-5216.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dehydroluciferyl adenylate | IC50: 6 nM | Photinus pyralis |  |
| dehydroluciferyl-CoA | IC50: 0.005 mM | Photinus pyralis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Photinus pyralis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-luciferin + O2 + ATP | - |
Photinus pyralis | oxidized D-luciferin + CO2 + H2O + AMP + diphosphate + hv | - |
? | |
| dehydroluciferyladenylate + CoA | - |
Photinus pyralis | dehydroluciferyl-CoA + ? | - |
? | |
| luciferyl adenylate + O2 | - |
Photinus pyralis | dehydroluciferyl adenylate + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| firefly luciferase | - |
Photinus pyralis |
| Luc | - |
Photinus pyralis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000006 | - |
IC50: 6 nM | Photinus pyralis | dehydroluciferyl adenylate | |
| 0.005 | - |
IC50: 0.005 mM | Photinus pyralis | dehydroluciferyl-CoA | |
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Release 2023.1 (January 2023)
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