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Literature summary for 1.13.11.34 extracted from

  • Mbarik, M.; Poirier, S.; Doiron, J.; Selka, A.; Barnett, D.; Cormier, M.; Touaibia, M.; Surette, M.
    Phenolic acid phenethylesters and their corresponding ketones Inhibition of 5-lipoxygenase and stability in human blood and HepaRG cells (2019), Pharmacol. Res. Perspect., 7, e00524 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.34

Inhibitors

Inhibitors Comment Organism Structure
(1E)-1-(2,5-dihydroxyphenyl)-5-phenylpent-1-en-3-one inhibits leukotriene biosynthesis in isolated human neutrophils and in whole blood Homo sapiens
(1E)-1-(3,4-dihydroxyphenyl)-6-phenylhex-1-en-3-one inhibits leukotriene biosynthesis in isolated human neutrophils and in whole blood Homo sapiens
(1E)-1-(4-hydroxy-3,5-dimethoxyphenyl)-5-phenylpent-1-en-3-one inhibits leukotriene biosynthesis in isolated human neutrophils and in whole blood, retains 50% of inhibitory activity after up to one hour of incubation Homo sapiens
2-phenylethyl (2E)-3-(2,5-dihydroxyphenyl)prop-2-enoate inhibits leukotriene biosynthesis in isolated human neutrophils and in whole blood Homo sapiens
2-phenylethyl (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate inhibits leukotriene biosynthesis in isolated human neutrophils and in whole blood Homo sapiens
caffeic acid phenethyl ester inhibits leukotriene biosynthesis in isolated human neutrophils and in whole blood Homo sapiens
zileuton
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P09917
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
Hepa-RG cell
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00029
-
 inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication Homo sapiens 2-phenylethyl (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate
0.00032
-
 inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication Homo sapiens 2-phenylethyl (2E)-3-(2,5-dihydroxyphenyl)prop-2-enoate
0.00041
-
 inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication Homo sapiens (1E)-1-(4-hydroxy-3,5-dimethoxyphenyl)-5-phenylpent-1-en-3-one
0.00051
-
 inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication Homo sapiens (1E)-1-(2,5-dihydroxyphenyl)-5-phenylpent-1-en-3-one
0.00052
-
 inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication Homo sapiens (1E)-1-(3,4-dihydroxyphenyl)-6-phenylhex-1-en-3-one
0.00097
-
 inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication Homo sapiens caffeic acid phenethyl ester
0.0023
-
 inhibition of 5-Lox product biosynthesis in polymorphonuclear leukocyte, 37°C, pH not specified in the publication Homo sapiens zileuton