Literature summary for 1.13.11.34 extracted from

Munoz-Osses, M.; Quiroz, J.; Vasquez-Martixadnez, Y.; Flores, E.; Navarrete, E.; Godoy, F.; Torrent, C.; Cortez-San Martin, M.; Gomez, A.; Mascayano, C.
Evaluation of cyrhetrenyl and ferrocenyl precursors as 5-lipoxygenase inhibitors - biological and computational studies (2021), New J. Chem., 45, 13360-13368 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking of inhibitor ferrocenyl carboxylic acid. The carboxylate group of the ferrocenyl complex may be oriented towards the catalytic site of the enzyme or may be located at the cavity entrance of the active site	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
cyrhetrenyl carboxylic acid	the compound is a good ROS generator	Homo sapiens
ferrocenyl carboxylic acid	mixed type inhibitor. The compound shows better antioxidant activity than the antioxidant Trolox	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09917	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.001	-	ferrocenyl carboxylic acid	pH 7.5, 23°C	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0025	-	pH 7.5, 23°C	Homo sapiens	ferrocenyl carboxylic acid
0.05	-	above 0.050 mM, pH 7.5, 23°C	Homo sapiens	cyrhetrenyl carboxylic acid

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Release 2023.1 (January 2023)