Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.34 extracted from

  • Phillips, O.A.; Bosso, M.A.; Ezeamuzie, C.I.
    Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors (2020), J. Enzyme Inhib. Med. Chem., 35, 1471-1482 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.34

Inhibitors

Inhibitors Comment Organism Structure
(R)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl) methyl)-N-hydroxyheptanamide
-
 Homo sapiens
(R)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl) methyl)-N-hydroxyoctanamide
-
 Homo sapiens
(R)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-N-hydroxypentanamide
-
 Homo sapiens
additional information synthesis of 5-(hydroxamic acid)methyl oxazolidinone derivatives as inhibitors. Increasing alkyl chain length on the hydroxamic acid moiety enhances activity and morpholinyl-containing derivatives are more active than N-acetyl-piperizinyl derivatives. The inhibitory effect of the compounds paralleles their effects in cell-based assays Homo sapiens
N-([(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)-N-hydroxy-2-methylpropanamide
-
 Homo sapiens
N-([(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)-N-hydroxycyclopropanecarboxamide
-
 Homo sapiens
zileuton
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P09917
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008
-
 pH 7.5, 25°C Homo sapiens zileuton
0.0016
-
 pH 7.5, 25°C Homo sapiens (R)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl) methyl)-N-hydroxyoctanamide
0.0019
-
 pH 7.5, 25°C Homo sapiens (R)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl) methyl)-N-hydroxyheptanamide
0.0033
-
 pH 7.5, 25°C Homo sapiens (R)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)-N-hydroxypentanamide
0.0035
-
 pH 7.5, 25°C Homo sapiens N-([(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)-N-hydroxycyclopropanecarboxamide
0.0039
-
 pH 7.5, 25°C Homo sapiens N-([(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)-N-hydroxy-2-methylpropanamide