Application | Comment | Organism |
---|---|---|
medicine | 15-LOX-1 and its metabolites (13-S-hydroxyoctadecadienoic acid and 15-S-hydroxyeicosatetraenoic acid) have anti-carcinogenic effects in colorectal cancer. 15-LOX-1 is possibly of prognostic value in stage IV colon cancer survival | Homo sapiens |
medicine | has anti-carcinogenic effects in colorectal cancer | Mus musculus |
Cloned (Comment) | Organism |
---|---|
HCT-116 and LoVo cells transfected with 15-LOX-1 vector | Homo sapiens |
transgenic mice models overexpressing 15-LOX in endothelial cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
anthraquinone | - |
Homo sapiens | |
baicalein | - |
Homo sapiens | |
caffeic acid | specific inhibitor of 15-LOX-1 | Homo sapiens | |
esculetin | - |
Homo sapiens | |
GATA-6 | inhibits non-steroidal anti-inflammatory drugs-induced transcription of 15-LOX-1 in colorectal cancer cells | Homo sapiens | |
additional information | 15-LOX-1 can be inactivated by epigenetic silencing, hypermethylation of the CpG islands of the 15-LOX-1 promoter results in its reduced transcription in cancers, e.g. lymphomas, lung, prostate and cervix cancers. Brominated phenol esters are potent 15-LOX-1 inhibitors | Homo sapiens | |
nor-dihydro-guaiaretic acid | - |
Homo sapiens | |
quercetin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | 15-LOX-1, in epithelial cells within the tumour and surrounding normal tissue | Homo sapiens | 5737 | - |
additional information | 15-LOX-1, in the stroma of fibroblasts | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
colon | 15-LOX-1 but not 15-LOX-2 | Homo sapiens | - |
cornea | 15-LOX-2 | Homo sapiens | - |
eosinophil | 15-LOX-1 | Homo sapiens | - |
epithelium | of the tracheobronchial tree, 15-LOX-1 | Homo sapiens | - |
fibroblast | 15-LOX-1 | Homo sapiens | - |
IEC-6 cell | - |
Rattus norvegicus | - |
lung | 15-LOX-2 | Homo sapiens | - |
additional information | 15-LOX-1 and -2 are preferentially expressed in normal tissue, present in HTB-38 cells | Homo sapiens | - |
additional information | is preferentially expressed in normal tissue | Mus musculus | - |
prostate | 15-LOX-2 | Homo sapiens | - |
reticulocyte | 15-LOX-1 | Homo sapiens | - |
skin | 15-LOX-1 and 15-LOX-2 | Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | both 15-LOX-1 and -2 | Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? | |
linoleic acid + O2 | both 15-LOX-1, 15-LOX-2 reacts with linoleic acid poorly | Homo sapiens | 13-S-hydroxyoctadecadienoic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12/15-LOX | - |
Mus musculus |
12/15-LOX | - |
Homo sapiens |
15-lipoxygenase-1 | - |
Homo sapiens |
15-LOX-1 | - |
Homo sapiens |
15-LOX-1 | - |
Rattus norvegicus |
15-LOX-2 | - |
Homo sapiens |
Alox15 | - |
Mus musculus |
reticulocyte-type of 15-LOX-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | demethylation of DNA in some cell lines increases 15-LOX-1 expression. Increased levels of 15-LOX-1 are associated with downregulation of GATA-6 in Caco-2 colon cancer cells treated with sodium butyrate to induce cell differentiation and apoptosis. Activation of the cGMP-PKG system can induce the cellular expression of 15-LOX-1 in SW-480 colon cancer cells. 5-aza-2-deoxycytidine increases 15-LOX-1 expression. Interleukin-4 upregulates the 15-LOX-1 gene in HTB-38 and Caco-2 human colorectal cancer cell lines. Interleukin-13 upregulates the 15-LOX-1 gene in HTB-38 and Caco-2 human colorectal cancer cell lines | up |
General Information | Comment | Organism |
---|---|---|
metabolism | shifting linoleic acid metabolism from 15-LOX-1 to COX-2 is procarcinogenic | Homo sapiens |
physiological function | 15-LOX-1 promotes mitogenic response to epidermal growth factor in fibroblasts and NaBT-induced apoptosis in colon cancer cells. Non-steroidal anti-inflammatory drugs-induced apoptosis mediated by 15-LOX-1/GATA-6 in colon cancer | Homo sapiens |
physiological function | inhibits tumour growth and metastasis. Enzyme promotes atherosclerosis and can inhibit growth and spread of lung (Lewis lung carcinoma model) and breast (mouse mammary adenocarcinoma model) cancer cells | Mus musculus |