Activating Compound | Comment | Organism | Structure |
---|---|---|---|
13-hydroperoxy-octadecadienoic acid | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed with hexa-His tags | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11-thialinoleic acid | is a noncompetitive inhibitor of 15-lipoxygenase-1 with respect to arachidonate or linoleic acid as substrates. Presence of inhibitor does not alter the product distribution for 15-lipoxygenase-1. It does not change the regioselectivity of 15-lipoxygenase-1 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
arachidonate | - |
Homo sapiens | |
0.0062 | - |
linoleic acid | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by one step Ni2+ affinity chromatography, more than 90% pure | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
reticulocyte | - |
Homo sapiens | - |
Storage Stability | Organism |
---|---|
-80°C, 10-20% glycerol | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? | |
linoleate + O2 | - |
Homo sapiens | (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
12/15-LO | - |
Homo sapiens |
15-lipoxygenase-1 | - |
Homo sapiens |
15-LO-1 | - |
Homo sapiens |