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Literature summary for 1.13.11.33 extracted from

  • Nagelin, M.H.; Srinivasan, S.; Lee, J.; Nadler, J.L.; Hedrick, C.C.
    12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1 (2008), Arterioscler. Thromb. Vasc. Biol., 28, 1811-1819.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.33

Cloned(Commentary)

Cloned (Comment) Organism
12/15LO stably overexpressed in mouse J774 macrophages Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Sus scrofa (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate 12/15LO eicosanoid products reduce cholesterol efflux to high density lipoproteins, regulate ATP-binding cassette transporter G1 expression and enhance ATP-binding cassette transporter G1 degradation and ATP-binding cassette transporter G1 serine phosphorylation ?
linoleic acid + O2
-
 Sus scrofa 13(S)-hydroxyoctadecadienoic acid 12/15LO eicosanoid products reduce cholesterol efflux to high density lipoproteins, regulate ATP-binding cassette transporter G1 expression and enhance ATP-binding cassette transporter G1 degradation and ATP-binding cassette transporter G1 serine phosphorylation ?

Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
-
 Sus scrofa
12/15LO
-
 Sus scrofa

General Information

General Information Comment Organism
physiological function 12/15LO activity in the vessel wall contributes to atherogenesis by impairing the macrophage ATP-binding cassette transporter G1 cholesterol efflux pathway. 12/15LO activity reduces high density lipoprotein-mediated cholesterol efflux, ATP-binding cassette transporter G1 cellular expression. 12/15LO activity does not affect ATP-binding cassette transporter G1 mRNA expression Sus scrofa