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Literature summary for 1.13.11.33 extracted from

  • Sadeghian, H.; Seyedi, S.M.; Saberi, M.R.; Arghiani, Z.; Riazi, M.
    Design and synthesis of eugenol derivatives, as potent 15-lipoxygenase inhibitors (2008), Bioorg. Med. Chem., 16, 890-901.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-allyl-2-methoxyphenyl 1-adamantanecarboxylate
-
Glycine max
4-allyl-2-methoxyphenyl 1-adamantanecarboxylate
-
Homo sapiens
4-allyl-2-methoxyphenyl 1-cyclohexanecarboxylate
-
Glycine max
4-allyl-2-methoxyphenyl 1-cyclohexanecarboxylate
-
Homo sapiens
4-allyl-2-methoxyphenyl 2-chlorobenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 2-chlorobenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl 2-fluorobenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 2-fluorobenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl 2-methylbenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 2-methylbenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl 2-pyridinecarboxylate
-
Glycine max
4-allyl-2-methoxyphenyl 2-pyridinecarboxylate
-
Homo sapiens
4-allyl-2-methoxyphenyl 3-chlorobenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 3-chlorobenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl 3-fluorobenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 3-fluorobenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl 3-methoxybenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 3-methoxybenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl 3-methylbenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 3-methylbenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl 4-chlorobenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 4-chlorobenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl 4-fluorobenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 4-fluorobenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl 4-methoxybenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 4-methoxybenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl 4-methylbenzoate
-
Glycine max
4-allyl-2-methoxyphenyl 4-methylbenzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl benzoate
-
Glycine max
4-allyl-2-methoxyphenyl benzoate
-
Homo sapiens
4-allyl-2-methoxyphenyl isonicotinate
-
Glycine max
4-allyl-2-methoxyphenyl isonicotinate
-
Homo sapiens
4-allyl-2-methoxyphenyl nicotinate
-
Glycine max
4-allyl-2-methoxyphenyl nicotinate
-
Homo sapiens
additional information quantitative structure activity relationship analysis using crystal structure, PDB ID 1IK3, EC 1.13.11.12, of the enzyme in complex with 13(S)-hydroperoxy-9(Z)-2,11(E)-octadecadienoic acid, docking studies, inhibitor binding structures, overview Glycine max
additional information docking studies, inhibitor binding structures, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Glycine max
-
-
-
Homo sapiens
-
isozymes 15-HLOa and 15-HLOb
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
linoleic acid + O2 reaction of EC 1.13.11.12 Glycine max (9Z,11E)-(13S)-13-hydroperoxy-octadeca-9,11-dienoate
-
?

Synonyms

Synonyms Comment Organism
15-hLO
-
Homo sapiens
15-lipoxygenase
-
Homo sapiens
15-lipoxygenase
-
Glycine max
arachidonic acid 15-lipoxygenase
-
Glycine max
More cf. EC 1.13.11.12 Glycine max
SLO
-
Glycine max
soybean 15-lipoxygenase
-
Glycine max
soybean lipoxygenase-3
-
Glycine max

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000017
-
-
Glycine max 4-allyl-2-methoxyphenyl 1-adamantanecarboxylate
0.0017
-
-
Glycine max 4-allyl-2-methoxyphenyl nicotinate
0.0021
-
-
Glycine max 4-allyl-2-methoxyphenyl 3-fluorobenzoate
0.0022
-
-
Glycine max 4-allyl-2-methoxyphenyl 1-cyclohexanecarboxylate
0.0023
-
-
Glycine max 4-allyl-2-methoxyphenyl isonicotinate
0.0044
-
-
Glycine max 4-allyl-2-methoxyphenyl benzoate
0.0052
-
-
Glycine max 4-allyl-2-methoxyphenyl 3-chlorobenzoate
0.0067
-
-
Glycine max 4-allyl-2-methoxyphenyl 2-fluorobenzoate
0.0072
-
-
Glycine max 4-allyl-2-methoxyphenyl 4-fluorobenzoate
0.0114
-
-
Glycine max 4-allyl-2-methoxyphenyl 3-methylbenzoate
0.0146
-
-
Glycine max 4-allyl-2-methoxyphenyl 4-methylbenzoate
0.019
-
-
Glycine max 4-allyl-2-methoxyphenyl 4-methoxybenzoate
0.023
-
-
Glycine max 4-allyl-2-methoxyphenyl 3-methoxybenzoate
0.0333
-
-
Glycine max 4-allyl-2-methoxyphenyl 2-pyridinecarboxylate
0.0772
-
-
Glycine max 4-allyl-2-methoxyphenyl 2-methylbenzoate
0.1343
-
-
Glycine max 4-allyl-2-methoxyphenyl 4-chlorobenzoate
0.168
-
-
Glycine max 4-allyl-2-methoxyphenyl 2-chlorobenzoate