Cloned (Comment) | Organism |
---|---|
expression of His-tagged isozyme 15-hLO-1, expression of isozyme 15-hLO-2 in Spodoptera frugiperda Sf9 cells using the baculovirus transfection system | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-alkyl benzopyran-4-ones | weak inhibition of isozymes 15-hLO-1 and 15-hLO-2 | Homo sapiens | |
2-alkyl-6-hydroxy-4-H-benzopyran-4-one | weak inhibition of isozymes 15-hLO-1 and 15-hLO-2 | Homo sapiens | |
3'-chloro-7,8-dihydroxyisoflavone | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
3-hydroxy-H-benzopyran-4-one derivatives | weak inhibition of isozymes 15-hLO-1 and 15-hLO-2 | Homo sapiens | |
4',6,7-trihydroxyisoflavan | - |
Homo sapiens | |
4',6,7-trihydroxyisoflavanone | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
4',6,7-trihydroxyisoflavone | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
4'-chloro-7,8-dihydroxyisoflavone | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
6,7-dihydroxy-2-t-butylbenzopyran-4-one | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
6,7-dihydroxy-3',4'-methylenedioxyisoflavan | - |
Homo sapiens | |
6,7-dihydroxy-3'-methylisoflavan | - |
Homo sapiens | |
6,7-dihydroxy-3'-methylisoflavanone | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
6,7-dihydroxy-4'-methoxyisoflavan | - |
Homo sapiens | |
6,7-dihydroxy-4'-methoxyisoflavanone | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
6,7-dihydroxyisoflavones | weak inhibition of isozymes 15-hLO-1 and 15-hLO-2 | Homo sapiens | |
6-hydroxy-2-pentyl-4H-benzopyran-4-one | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
7,8-dihydroxy-3',4'-dimethoxyisoflavan | - |
Homo sapiens | |
7,8-dihydroxy-3'-methylisoflavone | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
7,8-dihydroxy-3'-trifluoromethylisoflavone | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
7,8-dihydroxy-4'-methoxyisoflavan | - |
Homo sapiens | |
7,8-dihydroxy-4'-methylisoflavan | - |
Homo sapiens | |
7,8-dihydroxy-4'-methylisoflavone | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
7,8-dihydroxyisoflavone | weak inhibition of isozyme 15-hLO-2 | Homo sapiens | |
7-hydroxy-H-benzopyran-4-one derivatives | weak inhibition of isozymes 15-hLO-1 and 15-hLO-2 | Homo sapiens | |
additional information | comparison of structural requirements for flavonoid inhibitory potency and selectivity against platelet 12-hLO, EC 1.13.11.31, and reticulocyte 15-hLO-1 and prostate epithelial 15-hLO-2, overview, catechols are essential for high potency, isoflavones and isoflavanones tend to select against 12-hLO, isoflavans tend to select against isozyme 15-hLO-1, but few flavonoids target isozyme 15-hLO-2, molecular modeling analysis, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | Homo sapiens | - |
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes 15-hLO-1 and 15-hLO-2 | - |
Purification (Comment) | Organism |
---|---|
recombinant isozyme 15-hLO-2 from Spodoptera frugiperda Sf9 cells by anion exchange chromatography, recombinant His-tagged isozyme 15-hLO-1 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | isozyme 15-hLO-2 | Homo sapiens | - |
prostate | epithelium, isozyme 15-hLO-2 | Homo sapiens | - |
reticulocyte | isozyme 15-hLO-1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
arachidonate + O2 | preferred substrate of isozyme 15-hLO-2, reaction of EC 1.13.11.33 | Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate | - |
? | |
linoleic acid + O2 | preferred substrate of isozyme 15-hLO-1, reaction of EC 1.13.11.12 | Homo sapiens | (9Z,11E)-(13S)-13-hydroperoxy-octadeca-9,11-dienoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-hLO | - |
Homo sapiens |
More | cf. EC 1.13.11.12 | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00015 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 6,7-dihydroxy-4'-methoxyisoflavan | |
0.00021 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 6,7-dihydroxy-3'-methylisoflavan | |
0.00021 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 6,7-dihydroxy-3'-methylisoflavanone | |
0.00035 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 6,7-dihydroxy-3',4'-methylenedioxyisoflavan | |
0.00051 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 4',6,7-trihydroxyisoflavan | |
0.0016 | - |
pH 7.5, 22°C, isozyme 15-hLO-2 | Homo sapiens | 6,7-dihydroxy-4'-methoxyisoflavanone | |
0.0037 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 7,8-dihydroxy-4'-methoxyisoflavan | |
0.0038 | - |
pH 7.5, 22°C, isozyme 15-hLO-2 | Homo sapiens | 4',6,7-trihydroxyisoflavanone | |
0.0057 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 7,8-dihydroxy-4'-methylisoflavan | |
0.0062 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 3'-chloro-7,8-dihydroxyisoflavone | |
0.0078 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 7,8-dihydroxy-4'-methylisoflavone | |
0.0083 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 7,8-dihydroxy-3'-trifluoromethylisoflavone | |
0.0083 | - |
pH 7.5, 22°C, isozyme 15-hLO-2 | Homo sapiens | 6,7-dihydroxy-3'-methylisoflavan | |
0.009 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 4'-chloro-7,8-dihydroxyisoflavone | |
0.011 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 7,8-dihydroxy-3'-methylisoflavone | |
0.013 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 7,8-dihydroxyisoflavone | |
0.014 | - |
pH 7.5, 22°C, isozyme 15-hLO-2 | Homo sapiens | 6,7-dihydroxy-3'-methylisoflavanone | |
0.016 | - |
pH 7.5, 22°C, isozyme 15-hLO-2 | Homo sapiens | 6,7-dihydroxy-3',4'-methylenedioxyisoflavan | |
0.018 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 6,7-dihydroxy-2-t-butylbenzopyran-4-one | |
0.019 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 6,7-dihydroxy-4'-methoxyisoflavanone | |
0.038 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 6-hydroxy-2-pentyl-4H-benzopyran-4-one | |
0.049 | - |
pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 4',6,7-trihydroxyisoflavone | |
0.071 | - |
pH 7.5, 22°C, isozyme 15-hLO-2 | Homo sapiens | 4',6,7-trihydroxyisoflavan | |
0.1 | - |
above, pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 7,8-dihydroxy-3',4'-dimethoxyisoflavan | |
0.1 | - |
above, pH 7.5, 22°C, isozyme 15-hLO-1 | Homo sapiens | 4',6,7-trihydroxyisoflavanone | |
0.1 | - |
above, pH 7.5, 22°C, isozyme 15-hLO-2 | Homo sapiens | 7,8-dihydroxy-4'-methylisoflavan | |
0.1 | - |
above, pH 7.5, 22°C, isozyme 15-hLO-2 | Homo sapiens | 7,8-dihydroxy-3',4'-dimethoxyisoflavan | |
0.1 | - |
above, pH 7.5, 22°C, isozyme 15-hLO-2 | Homo sapiens | 7,8-dihydroxy-4'-methoxyisoflavan | |
0.1 | - |
above, pH 7.5, 22°C, isozyme 15-hLO-2 | Homo sapiens | 6,7-dihydroxy-4'-methoxyisoflavan |