Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + ROOH | Homo sapiens | - |
glutathione disulfide + ROH + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22352 | - |
- |
no activity in Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic smooth muscle cell | GPx-3 is detected at very low levels under basal conditions | Homo sapiens | - |
HAEC cell | GPx-3 is detected at very low levels under basal conditions | Homo sapiens | - |
HUVEC cell | GPx-3 is detected at very low levels under basal conditions | Homo sapiens | - |
plasma | GPx-3 is secreted into the plasma | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + ROOH | - |
Homo sapiens | glutathione disulfide + ROH + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione peroxidase-3 | - |
Homo sapiens |
GPx-3 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | GPx-3 is induced by MG132 in HUVEC cells with an exponential increase in GPx-3 mRNA up to 120fold of control levels within 48 h. GPx-3 is still upregulated by a factor of 3-4 even after 72 and 96 h of proteasome inhibition. HAEC cells upregulate GPx-3 by more than 40fold in response to MG132. Proteasome inhibition clearly induces GPx-3 in HAoSMCs by a factor of 18 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | glutathione peroxidase-3 is a key antioxidant enzyme in the plasma. Endothelial cell-derived GPx-3 protects the vasculature from oxidative stress | Homo sapiens |