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Literature summary for 1.11.1.9 extracted from

  • Tanaka, Y.; Tran, P.O.; Harmon, J.; Robertson, R.P.
    A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity (2002), Proc. Natl. Acad. Sci. USA, 99, 12363-12368.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
pancreatic islet the intrinsically low level of Gpx activity in the islets sets up the beta cell as an organelle particularly susceptible to oxidative stress secondary to high levels of glucose. Adenoviral overexpression of Gpx increases Gpx activity and protects islets against adverse effects of ribose Rattus norvegicus
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