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Literature summary for 1.11.1.9 extracted from
- The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin (2002), J. Biol. Chem., 277, 17062-17071.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of TcGPXI in transfected parasites confers increased resistance to exogenous hydroperoxides | Trypanosoma cruzi |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Trypanosoma cruzi | 5829 | - |
| glycosome | - |
Trypanosoma cruzi | 20015 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Trypanosoma cruzi | the enzyme can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, by glutathione. The activity of TcGPXI can also be linked to trypanothione reduction by an alternative pathway involving thioredoxin-like protein tryparedoxin. Overexpression of TcGPXI in transfected parasites confers increased resistance to exogenous hydroperoxides | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Trypanosoma cruzi |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.6868 | - |
- |
Trypanosoma cruzi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, by glutathione. The activity of TcGPXI can also be linked to trypanothione reduction by an alternative pathway involving thioredoxin-like protein tryparedoxin. Overexpression of TcGPXI in transfected parasites confers increased resistance to exogenous hydroperoxides | Trypanosoma cruzi | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione-dependent peroxidase I | - |
Trypanosoma cruzi |
| TcGPXI | - |
Trypanosoma cruzi |
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