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Literature summary for 1.11.1.6 extracted from

  • Harris, A.G.; Hazell, S.L.
    Localisation of Helicobacter pylori catalase in both the periplasm and cytoplasm, and its dependence on the twin-arginine target protein, KapA, for activity (2003), FEMS Microbiol. Lett., 229, 283-289.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the periplasmic enzyme is dependent on the twin-arginine target protein KapA for activity Helicobacter pylori

Cloned(Commentary)

Cloned (Comment) Organism
-
Helicobacter pylori

Protein Variants

Protein Variants Comment Organism
additional information construction of a mutant strain with a Thr501-truncated KatA and a KapA-deficient mutant strain, only the latter shows 5.5fold reduced KatA activity in the periplasm, the cytoplasmic activities remain unaltered in all cases, site-directed mutagenesis Helicobacter pylori

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm enzyme is produced in the cytoplasm and transported into the periplasm by a Sec-independent enzyme transport, the enzyme contains no signal peptide at the N-terminus Helicobacter pylori 5737
-
periplasm enzyme is produced in the cytoplasm and transported into the periplasm by a Sec-independent enzyme transport, the enzyme contains no signal peptide at the N-terminus Helicobacter pylori
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2O2 Helicobacter pylori enzyme is responsible for the protection of the Helicobacter pylori cells against phagocyte attack in the gastric mucosa by disumtation of H2O2 O2 + H2O
-
?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
gene katA, enzyme KatA
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information no signal peptide at the N-terminus Helicobacter pylori

Purification (Commentary)

Purification (Comment) Organism
native enzyme from cytoplasm and cell envelope Helicobacter pylori

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2O2
-
Helicobacter pylori O2 + H2O
-
?
H2O2 enzyme is responsible for the protection of the Helicobacter pylori cells against phagocyte attack in the gastric mucosa by disumtation of H2O2 Helicobacter pylori O2 + H2O
-
?
additional information the enzyme contains a unique tetra-lysine motif at the C-terminus which probably is required for interaction with protein KapA Helicobacter pylori ?
-
?

Subunits

Subunits Comment Organism
More determination and analysis of secondary enzyme structure Helicobacter pylori

Synonyms

Synonyms Comment Organism
KatA
-
Helicobacter pylori

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Helicobacter pylori