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Literature summary for 1.11.1.6 extracted from

  • Peraza, L.; Hansberg, W.
    Neurospora crassa catalases, singlet oxygen and cell differentiation (2002), Biol. Chem., 383, 569-575.
    View publication on PubMed

General Stability

General Stability Organism
isoform Cat-1, very stable for months, resistant to denaturizing agents such as urea or guanidine-HCl Neurospora crassa

Inhibitors

Inhibitors Comment Organism Structure
3-amino-1H-1,2,4-triazole
-
Aspergillus nidulans
3-amino-1H-1,2,4-triazole 50% inactivation in 1 h Neurospora crassa
hydroxyl radicals inactivation of isoform Cat-1 Neurospora crassa
KCN isoform Cat-2, IC50: 0.146 mM, catalase activity, IC50: 0.168 mM, peroxidase activity Neurospora crassa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
13
-
H2O2 isoform Cat-2 Neurospora crassa

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular isoform Cat-3 secreted Neurospora crassa
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
-
Neurospora crassa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2O2 Aspergillus nidulans
-
O2 + H2O
-
?
H2O2 Neurospora crassa two monofunctional catalases, Cat-1 and Cat-3, one catalase-peroxidase enzyme, Cat-2 O2 + H2O
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
isoform CatA
-
Neurospora crassa
-
isoforms Cat-1, Cat-2, Cat-3
-
Neurospora crassa Q8X182 isoform Cat-2
-

Oxidation Stability

Oxidation Stability Organism
oxidation by singlet oxygen Neurospora crassa

Purification (Commentary)

Purification (Comment) Organism
isoform Cat-2 Neurospora crassa
isoforms Cat-1, Cat-2, Cat-3 Neurospora crassa

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Aspergillus nidulans
-
cell culture
-
Neurospora crassa
-
conidium isoform Cat-1 mainly present Neurospora crassa
-
conidium isoform CatA Aspergillus nidulans
-
mycelium isoform Cat-3 mainly present Neurospora crassa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
130
-
isoform Cat-2, peroxidase activity with 3,3-diaminobenzidine Neurospora crassa
470
-
isoform Cat-2, peroxidase activity with ascorbate Neurospora crassa
1300
-
isoform Cat-2, peroxidase activity with guaiacol Neurospora crassa
1600
-
isoform Cat-2, peroxidase activity with o-dianisidine Neurospora crassa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3'-diaminobenzidine + H2O2 isoform Cat-2 Neurospora crassa ? + H2O
-
?
ascorbate + H2O2 isoform Cat-2 Neurospora crassa ? + H2O
-
?
H2O2
-
Aspergillus nidulans O2 + H2O
-
?
H2O2 two monofunctional catalases, Cat-1 and Cat-3, one catalase-peroxidase enzyme, Cat-2 Neurospora crassa O2 + H2O
-
?
o-dianisidine + H2O2 isoform Cat-2 Neurospora crassa ? + H2O
-
?
o-methoxyphenol + H2O2 isoform Cat-2 Neurospora crassa ? + H2O
-
?
o-methoxyphenol + H2O2 i.e. guaiacol Neurospora crassa ? + H2O
-
?

Subunits

Subunits Comment Organism
monomer 1 * 80000, isoforms Cat-1, Cat-3 Neurospora crassa

Synonyms

Synonyms Comment Organism
CatA
-
Aspergillus nidulans

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
100
-
isoform Cat-1, half-life: 70 min Neurospora crassa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
125000
-
H2O2 isoform Cat-2 Neurospora crassa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.75
-
isoform Cat-2, peroxidase activity Neurospora crassa
6.25
-
isoform Cat-2, catalase activity Neurospora crassa

Cofactor

Cofactor Comment Organism Structure
heme
-
Aspergillus nidulans
heme all isoforms have chlorine instead of ferro-protoheme IX at the active site Neurospora crassa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.168
-
isoform Cat-2, IC50: 0.146 mM, catalase activity, IC50: 0.168 mM, peroxidase activity Neurospora crassa KCN