KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetics, overview | Leishmania major |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is sensitive to increasing ionic strength | Leishmania major |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferrocytochrome c + H2O2 | Leishmania major | - |
2 ferricytochrome c + 2 H2O | - |
? | |
additional information | Leishmania major | Leishmania major peroxidase (LmP) exhibits both ascorbate and cytochrome c peroxidase activities, but cytochrome c is the natural substrate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 ferrocytochrome c + H2O2 + 2 H+ = 2 ferricytochrome c + 2 H2O | the intermediate Compound I forms once H2O2 is heterolytically cleaved, releasing a water molecule. The remaining O atom oxidizes the heme iron to Fe(IV) and an organic moiety to a cation radical. For most heme peroxidases, this moiety is the porphyrin ring. Upon two electron transfer events from two substrate molecules, the enzyme returns to the resting state with water occupying the active site | Leishmania major |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferrocytochrome c + H2O2 | - |
Leishmania major | 2 ferricytochrome c + 2 H2O | - |
? | |
additional information | Leishmania major peroxidase (LmP) exhibits both ascorbate and cytochrome c peroxidase activities, but cytochrome c is the natural substrate | Leishmania major | ? | - |
? | |
additional information | Leishmania major cytochrome c has an electropositive surface surrounding the exposed heme edge that serves as the docking site with redox partners. Kinetic assays performed with Leishmania major cytochrome c and the enzyme show that it is a much better substrate for LmP than horse heart cytochrome c | Leishmania major | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CCP | - |
Leishmania major |
cytochrome c peroxidase | - |
Leishmania major |
LmP | - |
Leishmania major |
General Information | Comment | Organism |
---|---|---|
additional information | enzyme-cytochrome c protein-protein docking and modeling, overview | Leishmania major |