Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | the enzyme is localized to the outer membrane of the mitochondria facing the cytoplasm | Mus musculus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q64521 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | GPD2 is tyrosine phosphorylated only in capacitated spermatozoa of wild type mice | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spermatozoon | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sn-glycerol 3-phosphate + menadione | - |
Mus musculus | glycerone phosphate + reduced menadione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycerol-3-phosphate dehydrogenase 2 | - |
Mus musculus |
GPD2 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mus musculus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Mus musculus | isoelectric focusing | 7.1 | 6.7 |
General Information | Comment | Organism |
---|---|---|
malfunction | in the absence of Gpd2, hyperactivation and acrosome reaction are significantly altered, and a few changes in protein tyrosine phosphorylation are observed during sperm capacitation. The testicular size of Gpd2-deficient animals is about 10% smaller than in wild type animals. Gpd2-null animals show a 4% reduction in tubular diameter and about 10% reduction in numbers of both spermatocytes and spermatids per seminiferous tubule | Mus musculus |
physiological function | GPD2 enables tyrosine phosphorylation during sperm capacitation. GPD2 activity is required for reactive oxygen species generation in mouse spermatozoa during capacitation | Mus musculus |