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Literature summary for 1.1.3.15 extracted from

  • Brush, E.J.; Hamilton, G.A.
    Thiol-glyoxylate adducts as substrates for rat kidney L-alpha-hydroxy acid oxidase (1981), Biochem. Biophys. Res. Commun., 103, 1194-1200.
    View publication on PubMed
Search for more literature for 1.1.3.15

Inhibitors

Inhibitors Comment Organism Structure
dihydrolipoate competitive inhibition of 2-hydroxybutyrate oxidation Rattus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
 propane-1,3-dithiol-glyoxylate adduct
-
 Rattus sp.
0.3
-
 O2 oxidation of 2-hydroxybutyrate Rattus sp.
0.4
-
 N-acetylcysteamine-glyoxylate adduct
-
 Rattus sp.
0.46
-
 O2 oxidation of propane-1,3-dithiol-glyoxylate adduct Rattus sp.
0.7
-
 pantetheine-glyoxylate adduct
-
 Rattus sp.
0.75
-
 2-mercaptoethanol-glyoxylate adduct
-
 Rattus sp.
1.2
-
 DL-2-hydroxybutyrate
-
 Rattus sp.
2.2
-
 coenzyme A-glyoxylate adduct
-
 Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DL-2-hydroxybutyrate + O2 Rattus sp.
-
 2-oxobutyrate + H2O2
-
 ?
glyoxylate + O2 Rattus sp. in the absence of any nucleophile less than 2% of the activity compared to glycolate ? + H2O2
-
 ?
thiol-glyoxylate adducts + O2 Rattus sp. may be the physiological substrates an oxalyl thioester + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-mercaptoethanol-glyoxylate adduct + O2
-
 Rattus sp. ?
-
 r
coenzyme A-glyoxylate adduct + O2
-
 Rattus sp. ?
-
 r
DL-2-hydroxybutyrate + O2
-
 Rattus sp. 2-oxobutyrate + H2O2
-
 ?
glyoxylate + O2 in the absence of any nucleophile less than 2% of the activity compared to glycolate Rattus sp. ? + H2O2
-
 ?
N-acetylcysteamine-glyoxylate adduct + O2
-
 Rattus sp. ?
-
 r
pantetheine-glyoxylate adduct + O2
-
 Rattus sp. ?
-
 r
propane-1,3-dithiol-glyoxylate adduct + O2
-
 Rattus sp. ?
-
 r
thiol-glyoxylate adducts + O2 may be the physiological substrates Rattus sp. an oxalyl thioester + H2O2
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.13
-
 dihydrolipoate
-
 Rattus sp.