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Literature summary for 1.1.3.13 extracted from
- Alcohol oxidase: a complex peroxisomal, oligomeric flavoprotein (2005), FEMS Yeast Res., 5, 975-983.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | induced by carbon starvation and during later stages of infection, deletion results in reduced pathogenicity | Fulvia fulva | |
| additional information | induced under conditions of penicillin production | Penicillium chrysogenum |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | in mutants defective in matrix protein import, cytosolic enzyme crystalloids are formed, mutants that contain enzymatically active enzyme in the cytosol are impaired in growth on methanol as a sole source of carbon and energy | Ogataea angusta |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Penicillium chrysogenum | 5777 | - |
| peroxisome | - |
Komagataella pastoris | 5777 | - |
| peroxisome | - |
[Candida] boidinii | 5777 | - |
| peroxisome | - |
Ogataea pini | 5777 | - |
| peroxisome | - |
Ogataea methanolica | 5777 | - |
| peroxisome | - |
Fulvia fulva | 5777 | - |
| peroxisome | is impaired in peroxisome biogenesis at 43°C but not at 37°C, the enzyme shows unusual oligomerisation in peroxisomes instead of in the cytosol, overiew | Ogataea angusta | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 600000 | - |
about | Penicillium chrysogenum |
| 600000 | - |
about | Komagataella pastoris |
| 600000 | - |
about | [Candida] boidinii |
| 600000 | - |
about | Ogataea angusta |
| 600000 | - |
about | Ogataea pini |
| 600000 | - |
about | Ogataea methanolica |
| 600000 | - |
about | Fulvia fulva |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methanol + O2 | Penicillium chrysogenum | - |
formaldehyde + H2O2 | - |
? |  |
| methanol + O2 | Komagataella pastoris | - |
formaldehyde + H2O2 | - |
? | |
| methanol + O2 | [Candida] boidinii | - |
formaldehyde + H2O2 | - |
? | |
| methanol + O2 | Ogataea pini | - |
formaldehyde + H2O2 | - |
? | |
| methanol + O2 | Ogataea methanolica | - |
formaldehyde + H2O2 | - |
? | |
| methanol + O2 | Fulvia fulva | - |
formaldehyde + H2O2 | - |
? | |
| methanol + O2 | Ogataea angusta | enzyme expression is tightly regulated, three regulatory sequences are involved | formaldehyde + H2O2 | - |
? | |
| additional information | Komagataella pastoris | the enzyme is the key enzyme of methanol metabolism in methylotrophic yeast species, overview | ? | - |
? | |
| additional information | [Candida] boidinii | the enzyme is the key enzyme of methanol metabolism in methylotrophic yeast species, overview | ? | - |
? | |
| additional information | Ogataea angusta | the enzyme is the key enzyme of methanol metabolism in methylotrophic yeast species, overview | ? | - |
? | |
| additional information | Ogataea pini | the enzyme is the key enzyme of methanol metabolism in methylotrophic yeast species, overview | ? | - |
? | |
| additional information | Ogataea methanolica | the enzyme is the key enzyme of methanol metabolism in methylotrophic yeast species, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Fulvia fulva | - |
gene AOX1 | - |
| Komagataella pastoris | - |
genes AOX1 and AOX2 | - |
| Ogataea angusta | - |
i.e. Pichia angusta, gene MOX | - |
| Ogataea methanolica | - |
genes AUG1 or MOD1 and AUG2 or MOD2 | - |
| Ogataea pini | - |
gene AOX1 | - |
| Penicillium chrysogenum | - |
gene AOX | - |
| [Candida] boidinii | - |
gene AOD1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | no enzyme expression when cells grow on glycerol, schematic overview of the biosynthetic pathway of the enzyme | Komagataella pastoris | - |
| additional information | schematic overview of the biosynthetic pathway of the enzyme | Penicillium chrysogenum | - |
| additional information | schematic overview of the biosynthetic pathway of the enzyme | [Candida] boidinii | - |
| additional information | schematic overview of the biosynthetic pathway of the enzyme | Ogataea angusta | - |
| additional information | schematic overview of the biosynthetic pathway of the enzyme | Ogataea pini | - |
| additional information | schematic overview of the biosynthetic pathway of the enzyme | Ogataea methanolica | - |
| additional information | schematic overview of the biosynthetic pathway of the enzyme | Fulvia fulva | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methanol + O2 | - |
Penicillium chrysogenum | formaldehyde + H2O2 | - |
? | |
| methanol + O2 | - |
Komagataella pastoris | formaldehyde + H2O2 | - |
? | |
| methanol + O2 | - |
[Candida] boidinii | formaldehyde + H2O2 | - |
? | |
| methanol + O2 | - |
Ogataea angusta | formaldehyde + H2O2 | - |
? | |
| methanol + O2 | - |
Ogataea pini | formaldehyde + H2O2 | - |
? | |
| methanol + O2 | - |
Ogataea methanolica | formaldehyde + H2O2 | - |
? | |
| methanol + O2 | - |
Fulvia fulva | formaldehyde + H2O2 | - |
? | |
| methanol + O2 | enzyme expression is tightly regulated, three regulatory sequences are involved | Ogataea angusta | formaldehyde + H2O2 | - |
? | |
| additional information | the enzyme is the key enzyme of methanol metabolism in methylotrophic yeast species, overview | Komagataella pastoris | ? | - |
? | |
| additional information | the enzyme is the key enzyme of methanol metabolism in methylotrophic yeast species, overview | [Candida] boidinii | ? | - |
? | |
| additional information | the enzyme is the key enzyme of methanol metabolism in methylotrophic yeast species, overview | Ogataea angusta | ? | - |
? | |
| additional information | the enzyme is the key enzyme of methanol metabolism in methylotrophic yeast species, overview | Ogataea pini | ? | - |
? | |
| additional information | the enzyme is the key enzyme of methanol metabolism in methylotrophic yeast species, overview | Ogataea methanolica | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| octamer | - |
Penicillium chrysogenum |
| octamer | - |
Komagataella pastoris |
| octamer | - |
[Candida] boidinii |
| octamer | - |
Ogataea pini |
| octamer | - |
Ogataea methanolica |
| octamer | - |
Fulvia fulva |
| octamer | structure analysis and overview | Ogataea angusta |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Mod1p | - |
Ogataea methanolica |
| Mod2p | - |
Ogataea methanolica |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | one prosthetic group per subunit, a flavoprotein | Penicillium chrysogenum | |
| FAD | one prosthetic group per subunit, a flavoprotein | Komagataella pastoris | |
| FAD | one prosthetic group per subunit, a flavoprotein | [Candida] boidinii | |
| FAD | one prosthetic group per subunit, a flavoprotein | Ogataea pini | |
| FAD | one prosthetic group per subunit, a flavoprotein | Fulvia fulva | |
| FAD | one prosthetic group per subunit, a flavoprotein, binding structure, fine tuning of the enzyme activity may be regulated via modifications of the cofactor FAD, one of these mechanisms involves the autoconversion of the naturally occurring FAD moiety to the modified form, i.e. mFAD or a-FAD | Ogataea angusta | |
| FAD | one prosthetic group per subunit, a flavoprotein, fine tuning of the enzyme activity may be regulated via modifications of the cofactor FAD, one of these mechanisms involves the autoconversion of the naturally occurring FAD moiety to the modified form, i.e. mFAD or a-FAD | Ogataea methanolica | |
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Release 2023.1 (January 2023)
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