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Literature summary for 1.1.2.3 extracted from

  • Tegoni, M.; Janot, J.M.; Labeyrie, F.
    Inhibition of L-lactate: cytochrome-c reductase (flavocytochrome b2) by product binding to the semiquinone transient. Loss of reactivity towards monoelectronic acceptors (1990), Eur. J. Biochem., 190, 329-342.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
pyruvate
-
Saccharomyces cerevisiae
pyruvate noncompetitive at low concentrations, uncompetitve at high concentrations Wickerhamomyces anomalus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
L-lactate
-
Saccharomyces cerevisiae
0.4
-
L-lactate
-
Wickerhamomyces anomalus
7.4
-
pyruvate
-
Saccharomyces cerevisiae
20
-
pyruvate
-
Wickerhamomyces anomalus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ bound to enzyme Saccharomyces cerevisiae
Fe2+ bound to enzyme Wickerhamomyces anomalus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactate + 2 ferricytochrome c Wickerhamomyces anomalus
-
pyruvate + 2 ferrocytochrome c + 2 H+
-
r
(S)-lactate + 2 ferricytochrome c Saccharomyces cerevisiae can feed electrons to respiratory chain at the level of cytochrome c pyruvate + 2 ferrocytochrome c + 2 H+
-
r

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Wickerhamomyces anomalus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + 2 ferricytochrome c
-
Saccharomyces cerevisiae pyruvate + 2 ferrocytochrome c + 2 H+
-
r
(S)-lactate + 2 ferricytochrome c
-
Wickerhamomyces anomalus pyruvate + 2 ferrocytochrome c + 2 H+
-
r
(S)-lactate + 2 ferricytochrome c can feed electrons to respiratory chain at the level of cytochrome c Saccharomyces cerevisiae pyruvate + 2 ferrocytochrome c + 2 H+
-
r
additional information ferricyanide used as electron acceptor Saccharomyces cerevisiae ?
-
?
additional information ferricyanide used as electron acceptor Wickerhamomyces anomalus ?
-
?
additional information electron acceptors other than ferricytochrome c used Saccharomyces cerevisiae ?
-
?
additional information electron acceptors other than ferricytochrome c used Wickerhamomyces anomalus ?
-
?

Cofactor

Cofactor Comment Organism Structure
additional information ferricyanide used as electron acceptor Saccharomyces cerevisiae
additional information ferricyanide used as electron acceptor Wickerhamomyces anomalus
additional information electron acceptors other than ferricytochrome c used Saccharomyces cerevisiae
additional information electron acceptors other than ferricytochrome c used Wickerhamomyces anomalus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2 5 pyruvate
-
Wickerhamomyces anomalus