Literature summary for 1.1.1.B40 extracted from

Garbrecht, M.R.; Klein, J.M.; McCarthy, T.A.; Schmidt, T.J.; Krozowski, Z.S.; Snyder, J.M.
11-beta Hydroxysteroid dehydrogenase type 2 in human adult and fetal lung and its regulation by sex steroids (2007), Pediatr. Res., 62, 26-31.

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Inhibitors

Inhibitors	Comment	Organism	Structure
17beta-estradiol	decrease in isoform HSD2 protein in male, but not female, fetal lung explant	Homo sapiens
additional information	no effect on isoform HSD2 protein level: 5alpha-dihydrotestosterone	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform HSD2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	adult and fetal lung and cultured fetal lung explant contain similar amounts of isoform HSD2 mRNA. Higher levels of HSD2 protein are detected in fetal lung tissue than in adult lung, with expression being restricted to a subset of epithelial cells in the fetal lung tissue. Differentiated fetal lung explants express higher levels of enzyme protein than undifferentiated explants	Homo sapiens	-

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Release 2023.1 (January 2023)