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Literature summary for 1.1.1.B40 extracted from
- Inhibitory effects of some possible endocrine-disrupting chemicals on the isozymes of human 11beta-hydroxysteroid dehydrogenase and expression of their mRNA in gonads and adrenal glands (2005), Environ. Sci., 12, 219-230.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-n-octylphenol | inhibition of kidney isozyme 11beta-HSD2, IC50: 0.0235 mM | Homo sapiens |  |
| 4-nonylphenol | inhibition of liver isozyme 11beta-HSD1 and kidney isozyme 11beta-HSD2, 11beta-HSD1 IC50: 49.3 mM, isozyme 11beta-HSD2 IC50: 0.0203 mM | Homo sapiens | |
| 4-t-octylphenol | inhibition of kidney isozyme 11beta-HSD2, IC50: 0.0089 mM | Homo sapiens | |
| dicyclohexyl phthalate | inhibition of kidney isozyme 11beta-HSD2, IC50: 0.0465 mM | Homo sapiens | |
| tributyltin | inhibition of kidney isozyme 11beta-HSD2, IC50: 0.0165 mM | Homo sapiens | |
| Triphenyltin | inhibition of kidney isozyme 11beta-HSD2, IC50: 0.0033 mM | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Homo sapiens | - |
| gonad | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| additional information | low expression in liver, ovary, prostate gland, and testis | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-HSD type 2 | - |
Homo sapiens |
| 11beta-HSD2 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0033 | - |
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C | Homo sapiens | Triphenyltin | |
| 0.0089 | - |
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C | Homo sapiens | 4-t-octylphenol | |
| 0.0165 | - |
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C | Homo sapiens | tributyltin | |
| 0.0203 | - |
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C | Homo sapiens | 4-nonylphenol | |
| 0.0235 | - |
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C | Homo sapiens | 4-n-octylphenol | |
| 0.0465 | - |
inhibition of kidney isozyme 11beta-HSD2, pH 7.4, 37°C | Homo sapiens | dicyclohexyl phthalate | |
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