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Literature summary for 1.1.1.B40 extracted from

  • Denari, D.; Ceballos, N.R.
    Seasonal changes in the activity of 11 beta-hydroxysteroid dehydrogenase in toad testes (2005), Ann. N. Y. Acad. Sci., 1040, 297-300.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glycyrrhetinic acid strong inhibition of isozyme 11beta-HSD2 Rhinella arenarum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00013
-
corticosterone pH 8.0, 28°C, isozyme 11beta-HSD2, R period Rhinella arenarum
0.00014
-
corticosterone pH 8.0, 28°C, isozyme 11beta-HSD2, PR period Rhinella arenarum
0.00028
-
corticosterone pH 8.0, 28°C, isozyme 11beta-HSD2, P period Rhinella arenarum

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome isozyme 11beta-HSD2 Rhinella arenarum
-
-
mitochondrion isozyme 11beta-HSD2 Rhinella arenarum 5739
-
additional information subcellular localization of isozyme 11beta-HSD2, overview, isozyme 11beta-HSD2 activity and plasma corticosterone are determined in toads from pre- (PR), post- (P), and reproductive (R) periods, overview Rhinella arenarum
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
corticosterone + NAD+ Rhinella arenarum isozyme 11beta-HSD2 11-dehydrocorticosterone + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Rhinella arenarum
-
isozyme 11beta-HSD2
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information isozyme 11beta-HSD2activity and plasma corticosterone are determined in toads from pre- (PR), post- (P), and reproductive (R) periods, activity is highest in P period, overview Rhinella arenarum
-
testis isozyme 11beta-HSD2 Rhinella arenarum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
isozyme 11beta-HSD2 activity and plasma corticosterone are determined in toads from pre- (PR), post- (P), and reproductive (R) periods, activity is highest in P period, overview Rhinella arenarum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
corticosterone + NAD+ isozyme 11beta-HSD2 Rhinella arenarum 11-dehydrocorticosterone + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
11 beta-hydroxysteroid dehydrogenase
-
Rhinella arenarum
11beta-HSD2
-
Rhinella arenarum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
28
-
assay at Rhinella arenarum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Rhinella arenarum

Cofactor

Cofactor Comment Organism Structure
NAD+ isozyme 11beta-HSD2, dependent on Rhinella arenarum