Inhibitors | Comment | Organism | Structure |
---|---|---|---|
A23187 | inhibits isozyme 11beta-HSD2 strongly | Homo sapiens | |
forskolin | slight inhibitory effect in absence of interleukin-1beta | Homo sapiens | |
interleukin-1beta | inhibits isozyme 11beta-HSD2, forskolin acts antagonistically strongly | Homo sapiens | |
additional information | inhibitory effects, antogonistic and agonistic effects of inhibitors and compounds, overview, no inhibition of isozyme 11beta-HSD2 by 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate | Homo sapiens | |
Nifed | inhibits isozyme 11beta-HSD2 slightly | Homo sapiens | |
SQ-22536 | inhibits isozyme 11beta-HSD2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | Homo sapiens | isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+ | cortisone + NADH | - |
ir | |
additional information | Homo sapiens | proinflammatory cytokines inhibit placental isozyme 11beta-HSD2 activity through Ca2+ and cAMP pathways, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme 11beta-HSD2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | almost exclusively isozyme 11beta-HSD2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+ | Homo sapiens | cortisone + NADH | - |
ir | |
additional information | proinflammatory cytokines inhibit placental isozyme 11beta-HSD2 activity through Ca2+ and cAMP pathways, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD2 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | 11beta-HSD2 | Homo sapiens |