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Literature summary for 1.1.1.93 extracted from

  • Tipton, P.A.
    Tartrate dehydrogenase, an enzyme with multiple catalytic activities (2000), Protein Pept. Lett., 7, 323-332.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
NH4+ required Pseudomonas putida

Inhibitors

Inhibitors Comment Organism Structure
D-malate competitive versus L-tartrate and meso-tartate Pseudomonas putida
L-Tartrate competitive versus meso-tartrate and D-malate Pseudomonas putida
meso-tartrate competitive versus L-tartrate and D-malate Pseudomonas putida

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
isopropylmalate
-
Pseudomonas putida
0.05
-
D-malate
-
Pseudomonas putida
0.06
-
meso-tartrate
-
Pseudomonas putida
1
-
L-Tartrate
-
Pseudomonas putida

Metals/Ions

Metals/Ions Comment Organism Structure
K+ monovalent cation required, maximal activity with K+ and Rb+ Pseudomonas putida
Mg2+ supports catalytic activity Pseudomonas putida
Mn2+ required Pseudomonas putida
Mn2+ supports catalytic activity Pseudomonas putida
Rb+ monovalent cation required, maximal activity with K+ and Rb+ Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-(+)-tartrate + NAD+ Pseudomonas putida enzyme production is induced by growth on L-(+)-tartrate as the sole carbon source oxaloglycolate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas putida
-
-
-

Reaction

Reaction Comment Organism Reaction ID
tartrate + NAD+ = oxaloglycolate + NADH + H+ A-side dehydrogenase, i.e. the hydride is transferred from the substrate to the pro-R position of C4 of NADH Pseudomonas putida

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-malate + NAD+
-
Pseudomonas putida pyruvate + CO2 + NADH D-malate is oxidized to oxaloacetate, which remains bound to the enzyme and undergoes decarboxylation to yield pyruvate ?
isopropylmalate + NAD+
-
Pseudomonas putida ?
-
?
L-(+)-tartrate + NAD+ enzyme production is induced by growth on L-(+)-tartrate as the sole carbon source Pseudomonas putida oxaloglycolate + NADH
-
?
L-tartrate + NAD+ oxidation occurs at 2R position Pseudomonas putida oxaloglycolate + NADH + H+ 3R-oxaloglycolate ?
meso-tartrate + NAD+ oxidation occurs at 2R oposition Pseudomonas putida oxaloglycolate + NADH + H+ meso-tartrate is oxidized to 3S-oxaloglycolate, followed by decarboxylation to hydroxypyruvate ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.2
-
isopropylmalate
-
Pseudomonas putida
0.483
-
L-Tartrate
-
Pseudomonas putida
0.617
-
meso-tartrate
-
Pseudomonas putida
19.7
-
D-malate
-
Pseudomonas putida

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Pseudomonas putida