Literature summary for 1.1.1.81 extracted from

Zong, C.; Nie, X.; Zhang, D.; Ji, Q.; Qin, Y.; Wang, L.; Jiang, D.; Gong, C.; Liu, Y.; Zhou, G.
Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis (2016), Pathol. Res. Pract., 212, 365-371.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-glycerate + NAD+	Homo sapiens	-	hydroxypyruvate + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UBQ7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HT-29 cell	-	Homo sapiens	-
intestinal epithelial cell	-	Homo sapiens	-
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glycerate + NAD+	-	Homo sapiens	hydroxypyruvate + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
GRHPR	bifunctional enzyme with glyoxylate reductase and hydroxypyruvate reductase activities	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	upregulation of glyoxylate reductase/hydroxypyruvate reductase is associated with intestinal epithelial cells apoptosis in trinitrobenzenesulfonic acid-induced colitis	Homo sapiens

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Release 2023.1 (January 2023)