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Literature summary for 1.1.1.8 extracted from

  • Chowdhury, S.K.; Gemin, A.; Singh, G.
    High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines (2005), Biochem. Biophys. Res. Commun., 333, 1139-1145.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Homo sapiens 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sn-glycerol 3-phosphate + NAD+ Homo sapiens mGPDH is involved in maintaining a high rate of glycolysis and is an important site of electron leakage leading to production of reactive oxygen species in prostate cancer cells dihydroxyacetone phosphate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
CL-1 prostate cancer cell mGPDH abundance and activity is significantly elevated in prostate cancer cell lines when compared to the normal prostate epithelial cell line PNT1A Homo sapiens
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DU-145 cell mGPDH abundance and activity is significantly elevated in prostate cancer cell lines when compared to the normal prostate epithelial cell line PNT1A Homo sapiens
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LNCaP cell mGPDH abundance and activity is significantly elevated in prostate cancer cell lines when compared to the normal prostate epithelial cell line PNT1A Homo sapiens
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PC-3 cell mGPDH abundance and activity is significantly elevated in prostate cancer cell lines when compared to the normal prostate epithelial cell line PNT1A Homo sapiens
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PNT1A cell mGPDH abundance and activity is significantly elevated in prostate cancer cell lines when compared to the normal prostate epithelial cell line PNT1A Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sn-glycerol 3-phosphate + NAD+
-
Homo sapiens dihydroxyacetone phosphate + NADH + H+
-
?
sn-glycerol 3-phosphate + NAD+ mGPDH is involved in maintaining a high rate of glycolysis and is an important site of electron leakage leading to production of reactive oxygen species in prostate cancer cells Homo sapiens dihydroxyacetone phosphate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
mGPDH
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Homo sapiens