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Literature summary for 1.1.1.8 extracted from
- Fast purification and kinetic studies of the glycerol-3-phosphate dehydrogenase from the yeast Saccharomyces cerevisiae (1996), Biotechnology, 49, 19-27.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | competitive inhibitor to NADH at physiological concentration | Saccharomyces cerevisiae |  |
| phosphate | competitive inhibitor against dihydroxyacetone phosphate, non-competitive inhibitor against NADH | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sn-glycerol 3-phosphate + NAD+ | Saccharomyces cerevisiae | - |
dihydroxyacetone phosphate + NADH + H+ | - |
? | |
| sn-glycerol 3-phosphate + NAD+ | Saccharomyces cerevisiae YSH 11-6B | - |
dihydroxyacetone phosphate + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
| Saccharomyces cerevisiae YSH 11-6B | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+ | equilibrium random-bi-bi reaction mechanism | Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 50.1 | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sn-glycerol 3-phosphate + NAD+ | - |
Saccharomyces cerevisiae | dihydroxyacetone phosphate + NADH + H+ | - |
? | |
| sn-glycerol 3-phosphate + NAD+ | - |
Saccharomyces cerevisiae YSH 11-6B | dihydroxyacetone phosphate + NADH + H+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 43000-47000, SDS-PAGE | Saccharomyces cerevisiae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 51 | - |
- |
Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
most active | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Saccharomyces cerevisiae | |
| NADH | - |
Saccharomyces cerevisiae | |
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