General Stability | Organism |
---|---|
stable on freezing and thawing an ultrasonication | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | - |
Rattus norvegicus | |
D,L-3-hydroxybutyrate | non-competitive, Ki: 200 mM in liver homogenates, little effect in soluble fraction from disintegrated mitochondria | Rattus norvegicus | |
EDTA | weak inhibition at high concentration, little effect in soluble extract of disintegrated mitochondria | Rattus norvegicus | |
L-cysteine | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
15 | - |
1-aminopropan-2-ol | liver homogenates | Rattus norvegicus | |
200 | - |
D,L-4-amino-3-hydroxybutyrate | liver homogenates | Rattus norvegicus | |
200 | - |
1-aminopropan-2-ol | soluble extract of disintegrated mitochondria | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | inhibitory at all concentrations | Rattus norvegicus | |
Mg2+ | slightly activating at 1.3 mM, inhibitory above 3 mM | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-1-aminopropan-2-ol + NAD+ | Rattus norvegicus | possible role in carnitine metabolism | aminoacetone + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
muscle | - |
Rattus norvegicus | - |
spleen | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.001 | - |
soluble extract of disintegrated mitochondria | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D,L-1-aminopropan-2-ol + NAD+ | - |
Rattus norvegicus | aminoacetone + NADH | - |
? | |
D,L-4-amino-3-hydroxybutyrate + NAD+ | - |
Rattus norvegicus | 4-amino-3-oxobutyrate + NADH | - |
? | |
L-1-aminopropan-2-ol + NAD+ | - |
Rattus norvegicus | aminoacetone + NADH | - |
? | |
L-1-aminopropan-2-ol + NAD+ | possible role in carnitine metabolism | Rattus norvegicus | aminoacetone + NADH | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.1 | - |
soluble extract of disintegrated mitochondria | Rattus norvegicus |
9.8 | - |
liver homogenates | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 11 | very low activity at pH 7.5, 60% of activity at pH 11 in liver homogenates | Rattus norvegicus |
8.5 | 10.5 | 40% of activity in soluble extract of disintegrated mitochondria | Rattus norvegicus |