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Literature summary for 1.1.1.64 extracted from

  • Harada, K.; Kubo, H.; Tanaka, A.; Nishioka, K.
    Identification of oxazolidinediones and thiazolidinediones as potent 17beta-hydroxysteroid dehydrogenase type 3 inhibitors (2012), Bioorg. Med. Chem. Lett., 22, 504-507.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-(3-bromo-4-hydroxybenzyl)-3-(4-methoxyphenyl)-1,3-thiazol-2-one starting compound for high-throughput screening. IC50 value 570 nM in cell-based assay Homo sapiens
5-(3-bromo-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-one compound demonstrates significant selectivity for isoform 17beta-hydroxysteroid dehydrogenase type 3 over the related isoenzymes and nuclear receptors. IC50 value 14 nM in cell-based assay Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P37058
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-

Synonyms

Synonyms Comment Organism
3beta-hydroxysteroid dehydrogenase type 3
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Homo sapiens