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Literature summary for 1.1.1.64 extracted from

  • Geissler, W.M.; Davis, D.L.; Wu, L.; Bradshaw, K.D.; Patel, S.; Mendoca, B.B.; Elliston, K.O.; Wilson, J.D.; Russell, D.W.; Andersson, S.
    Male pseudohermaphroditism caused by mutations of testicular 17beta-hydroxysteroid dehydrogenase 3 (1994), Nature Genet., 7, 34-39.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
A203V inactive enzyme Homo sapiens
M235V inactive enzyme Homo sapiens
R80Q
-
Homo sapiens
S232L inactive enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-estradiol + NADP+ Homo sapiens
-
estrone + NADPH
-
r
testosterone + NADP+ Homo sapiens 17beta-hydroxysterod dehydrogenase 3, reduction of androst-4-ene-3,17-dione is preferred androst-4-ene-3,17-dione + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NADP+
-
Homo sapiens estrone + NADPH
-
r
testosterone + NADP+ 17beta-hydroxysteroid dehydrogenase 3, reduction of androst-4-ene-3,17-dione is preferred Homo sapiens androst-4-ene-3,17-dione + NADPH + H+
-
r
testosterone + NADP+ 17beta-hydroxysterod dehydrogenase 3, reduction of androst-4-ene-3,17-dione is preferred Homo sapiens androst-4-ene-3,17-dione + NADPH + H+
-
r

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens