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Literature summary for 1.1.1.62 extracted from
- Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) (2009), J. Med. Chem., 52, 3259-3264.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,5-dibromosalicylic acid | - |
Homo sapiens |  |
| 3-bromo-5-phenylsalicylic acid | - |
Homo sapiens | |
| 3-phenyl-5-bromosalicylic acid | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-tetralol + NADP+ | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 20alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
| AKR1C1 | - |
Homo sapiens |
| AKR1C2 | - |
Homo sapiens |
| AKR1C3 | - |
Homo sapiens |
| AKR1C4 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000004 | - |
3-bromo-5-phenylsalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
| 0.000009 | - |
3,5-dibromosalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
| 0.000082 | - |
3,5-dibromosalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
| 0.000087 | - |
3-bromo-5-phenylsalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
| 0.00014 | - |
3-phenyl-5-bromosalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
| 0.00197 | - |
3-phenyl-5-bromosalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
| 0.0042 | - |
3-bromo-5-phenylsalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
| 0.0182 | - |
3-bromo-5-phenylsalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
| 0.021 | - |
3-phenyl-5-bromosalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
| 0.023 | - |
3,5-dibromosalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
| 0.0457 | - |
3,5-dibromosalicylic acid | pH not specified in the publication, 25°C | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00046 | - |
pH not specified in the publication, 25°C | Homo sapiens | 3-bromo-5-phenylsalicylic acid | |
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