Literature summary for 1.1.1.62 extracted from

Fournier, D.; Poirier, D.; Mazumdar, M.; Lin, S.X.
Design and synthesis of bisubstrate inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: overview and perspectives (2008), Eur. J. Med. Chem., 43, 2298-2306.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(16alpa,17beta)-16-(3-bromopropyl)estra-1(10),2,4-triene-3,17-diol	EM-251	Homo sapiens
(3-amino-5-[13-[(16beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-16-yl]tridecyl]phenyl)acetic acid	-	Homo sapiens
(3-[(4-aminophenyl)carbonyl]-5-[13-[(16beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-16-yl]tridecyl]phenyl)acetic acid	-	Homo sapiens
(3-[13-[(16beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-16-yl]tridecyl]phenyl)acetic acid	-	Homo sapiens
5'-O-[9-[(16beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-16-yl]nonanoyl]adenosine	EM-1745, bisubstrate inhibitor of 17beta-HSD1	Homo sapiens
EM-1745	bisubstrate inhibitor of 17beta-HSD1	Homo sapiens
N-butyl-6-[[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]oxy]-N-methylhexanamide	-	Homo sapiens
N-butyl-6-[[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]sulfanyl]-N-methylhexanamide	EM-678	Homo sapiens
N-butyl-7-[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]-N-methylheptanamide	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14061	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dehydroepiandrosterone + NAD(P)H	-	Homo sapiens	androst-5-ene-3beta,17beta-diol + NAD(P)+	-	?
estradiol-17beta + NAD(P)+	-	Homo sapiens	estrone + NAD(P)H + H+	-	?

Synonyms

Synonyms	Comment	Organism
17beta-HSD1	-	Homo sapiens
type 1 17beta-hydroxysteroid dehydrogenase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD(P)+	-	Homo sapiens

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Release 2023.1 (January 2023)