Application | Comment | Organism |
---|---|---|
medicine | 17beta-HSD1 inhibitors such as STX1040 may provide a treatment for hormone-dependent breast cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
the complete 17beta-HSD1 (HSD17B131) and 17beta-HSD12 (HSD17B12) cDNA sequences are cloned into the pCEP4 expression vector for expression in 293-EBNA cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
STX1040 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14061 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell line | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NAD(P)H + H+ | - |
Homo sapiens | estradiol-17beta + NAD(P)+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD1 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000027 | - |
- |
Homo sapiens | STX1040 |