Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(2-furylmethyl)-8-hydroxy-2-(2-phenylethyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 33% inhibition at 100 nM, 78% inhibition at 0.001 mM | Homo sapiens | |
3-benzyl-2-(2-bromo-3,4,5-trimethoxyphenyl)-8-hydroxy[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 87% inhibition at 100 nM, 95% inhibition at 0.001 mM. IC50: 5 nM | Homo sapiens | |
3-benzyl-8-hydroxy-2-(2-methylprop-1-en-1-yl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 82% inhibition at 100 nM, 97% inhibition at 0.001 mM | Homo sapiens | |
3-benzyl-8-hydroxy-2-(2-thienyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 83% inhibition at 100 nM, 89% inhibition at 0.001 mM | Homo sapiens | |
3-benzyl-8-hydroxy-2-(3,4,5-trimethoxyphenyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 94% inhibition at 100 nM, 99% inhibition at 0.001 mM. IC50: 5 nM | Homo sapiens | |
3-benzyl-8-hydroxy-2-(3-methoxyphenyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 89% inhibition at 100 nM, 95% inhibition at 0.001 mM | Homo sapiens | |
3-butyl-8-hydroxy-2-(3,4,5-trimethoxyphenyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 86% inhibition at 100 nM, 95% inhibition at 0.001 mM | Homo sapiens | |
3-[(5-bromofuran-2-yl)methyl]-8-hydroxy-2-(3,4,5-trimethoxyphenyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 94% inhibition at 100 nM, 99% inhibition at 0.001 mM | Homo sapiens | |
5-benzyl-3-(furan-2-ylmethyl)-8-hydroxy-2-(2-phenylethyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 5% inhibition at 100 nM, 26% inhibition at 0.001 mM | Homo sapiens | |
5-butyl-3-(furan-2-ylmethyl)-8-hydroxy-2-(2-phenylethyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 9% inhibition at 100 nM, 27% inhibition at 0.001 mM | Homo sapiens | |
6-butyl-3-(furan-2-ylmethyl)-8-hydroxy-2-(2-phenylethyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 52% inhibition at 100 nM, 81% inhibition at 0.001 mM | Homo sapiens | |
8-hydroxy-3-(2-methylbutyl)-2-(3,4,5-trimethoxyphenyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 91% inhibition at 100 nM, 94% inhibition at 0.001 mM | Homo sapiens | |
8-hydroxy-3-(2-methylpropyl)-2-(3,4,5-trimethoxyphenyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 93% inhibition at 100 nM, 98% inhibition at 0.001 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14061 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NAD(P)H + H+ | - |
Homo sapiens | estradiol-17beta + NAD(P)+ | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000005 | - |
87% inhibition at 100 nM, 95% inhibition at 0.001 mM. IC50: 5 nM | Homo sapiens | 3-benzyl-2-(2-bromo-3,4,5-trimethoxyphenyl)-8-hydroxy[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | |
0.000005 | - |
94% inhibition at 100 nM, 99% inhibition at 0.001 mM. IC50: 5 nM | Homo sapiens | 3-benzyl-8-hydroxy-2-(3,4,5-trimethoxyphenyl)[1]benzothieno[2,3-d]pyrimidin-4(3H)-one |