Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.62 extracted from

  • Brown, W.M.; Metzger, L.E.; Barlow, J.P.; Hunsaker, L.A.; Deck, L.M.; Royer, R.E.; Vander Jagt, D.L.
    17-beta-Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold (2003), Chem. Biol. Interact., 143-144, 481-491.
    View publication on PubMed

Application

Application Comment Organism
medicine attractive drug target in hormone-sensitive breast cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
gossypol and derivatives of gossypol, competitive with respect to NAD+ in reverse reaction Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone + NAD(P)H Homo sapiens final step in the synthesis of active estrogens estradiol-17beta + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
17beta-HSD1
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone + NAD(P)H
-
Homo sapiens estradiol-17beta + NAD(P)+
-
r
estrone + NAD(P)H final step in the synthesis of active estrogens Homo sapiens estradiol-17beta + NAD(P)+
-
r

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens
NADPH
-
Homo sapiens