Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.62 extracted from

  • Carstensen, J.F.; Tesdorpf, J.G.; Kaufmann, M.; Markus, M.M.; Husen, B.; Leenders, F.; Jakob, F.; de Launoit, Y.; Adamski, J.
    Characterization of 17beta-hydroxysteroid dehydrogenase IV (1996), J. Endocrinol., 150, S3-12.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
2 * 32000, SDS-PAGE Sus scrofa
75000
-
sucrose density gradient centrifugation Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa expression is stimulated 2fold by dexamethasone but is completly downregulated by phorbol ester ?
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
17beta-hydroxysteroid dehydrogenase IV
-

Posttranslational Modification

Posttranslational Modification Comment Organism
no glycoprotein
-
Sus scrofa
proteolytic modification 17beta-hydroxysteroid dehydrogenase IV is coded by 2.9 kb mRNA translated to an 80000 Da protein which is N-terminally cleaved to a 32000 Da enzyme Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
gonad granulosa cells, Leydig cells and Sertoli cells Sus scrofa
-
kidney
-
Sus scrofa
-
liver
-
Sus scrofa
-
ovary
-
Sus scrofa
-
testis
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estradiol-17beta + NAD+ reduction of estrone is 400fold slower than oxidation of 17beta-estradiol Sus scrofa estrone + NADH
-
r
estradiol-17beta + NADP+ activity with NADP+ is only 30% of the activity with NAD+ Sus scrofa estrone + NADPH
-
r
estrone + NADH reduction of estrone is 400fold slower than oxidation of 17beta-estradiol Sus scrofa estradiol-17beta + NAD+
-
r
additional information expression is stimulated 2fold by dexamethasone but is completly downregulated by phorbol ester Sus scrofa ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 32000, SDS-PAGE Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Sus scrofa
NAD+ activity with NADP+ is only 30% of the activity with NAD+ Sus scrofa
NADH cofactor Sus scrofa
NADP+ cofactor Sus scrofa
NADP+ activity with NADP+ is only 30% of the activity with NAD+ Sus scrofa