Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
2 * 32000, SDS-PAGE | Sus scrofa |
75000 | - |
sucrose density gradient centrifugation | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Sus scrofa | expression is stimulated 2fold by dexamethasone but is completly downregulated by phorbol ester | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
17beta-hydroxysteroid dehydrogenase IV | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
no glycoprotein | - |
Sus scrofa |
proteolytic modification | 17beta-hydroxysteroid dehydrogenase IV is coded by 2.9 kb mRNA translated to an 80000 Da protein which is N-terminally cleaved to a 32000 Da enzyme | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gonad | granulosa cells, Leydig cells and Sertoli cells | Sus scrofa | - |
kidney | - |
Sus scrofa | - |
liver | - |
Sus scrofa | - |
ovary | - |
Sus scrofa | - |
testis | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estradiol-17beta + NAD+ | reduction of estrone is 400fold slower than oxidation of 17beta-estradiol | Sus scrofa | estrone + NADH | - |
r | |
estradiol-17beta + NADP+ | activity with NADP+ is only 30% of the activity with NAD+ | Sus scrofa | estrone + NADPH | - |
r | |
estrone + NADH | reduction of estrone is 400fold slower than oxidation of 17beta-estradiol | Sus scrofa | estradiol-17beta + NAD+ | - |
r | |
additional information | expression is stimulated 2fold by dexamethasone but is completly downregulated by phorbol ester | Sus scrofa | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 32000, SDS-PAGE | Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | cofactor | Sus scrofa | |
NAD+ | activity with NADP+ is only 30% of the activity with NAD+ | Sus scrofa | |
NADH | cofactor | Sus scrofa | |
NADP+ | cofactor | Sus scrofa | |
NADP+ | activity with NADP+ is only 30% of the activity with NAD+ | Sus scrofa |