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Literature summary for 1.1.1.62 extracted from
- Studies on 17beta-hydroxysteroid dehydrogenase in human endometrium and endometrial carcinoma (1975), Acta Endocrinol., 79, 146-156.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0033 | - |
estradiol-17beta | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| uterine endometrium | secretory | Homo sapiens | - |
| uterine endometrium | endometrial carcinoma | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| androstenedione + NADPH + H+ | - |
Homo sapiens | testosterone + NADP+ | - |
r | |
| estradiol-17beta + NAD+ | - |
Homo sapiens | estrone + NADH | - |
r | |
| estradiol-17beta + NADP+ | maximal activity with NADP+ is approximately 1/3 of that with NAD+ | Homo sapiens | estrone + NADPH | - |
r | |
| estrone + NADH | - |
Homo sapiens | estradiol-17beta + NAD+ | - |
r | |
| estrone + NADPH + H+ | - |
Homo sapiens | estradiol-17beta + NADP+ | - |
r | |
| testosterone + NADP+ | - |
Homo sapiens | 4-androstene-3,17-dione + NADPH + H+ | androstenedione | r | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
oxidation of estradiol-17beta | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
enzyme is cold sensitive, cold inactivation is reduced by NAD+, NADP+, estradiol or glycerol | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
reduction of estrone | Homo sapiens |
| 9.5 | - |
oxidation of estradiol-17beta | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | cofactor | Homo sapiens | |
| NAD+ | maximal activity with NADP+ is approximately 1/3 of that with NAD+ | Homo sapiens | |
| NADH | cofactor | Homo sapiens | |
| NADP+ | cofactor | Homo sapiens | |
| NADP+ | maximal activity with NADP+ is approximately 1/3 of that with NAD+ | Homo sapiens | |
| NADPH | cofactor | Homo sapiens | |
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Release 2023.1 (January 2023)
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