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Literature summary for 1.1.1.53 extracted from

  • Ghosh, D.; Wawrzak, Z.; Weeks, C.M.; Duax, W.L.; Erman, M.
    The refined three-dimensional structure of 3alpha,20beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases (1994), Structure, 2, 629-640.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
refined model, also with bound cortisone molecule Streptomyces exfoliatus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
 4 * 28000, about, crystal structure and sequence analysis Streptomyces exfoliatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H Streptomyces exfoliatus enzyme belongs to the group of short-chain dehydrogenases ?
-
 r

Organism

Organism UniProt Comment Textmining
Streptomyces exfoliatus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+ deduced reaction mechanism from crystal structure model Streptomyces exfoliatus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H enzyme belongs to the group of short-chain dehydrogenases Streptomyces exfoliatus ?
-
 r

Subunits

Subunits Comment Organism
tetramer 4 * 28000, about, crystal structure and sequence analysis Streptomyces exfoliatus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Streptomyces exfoliatus