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Literature summary for 1.1.1.53 extracted from

  • Adachi, S.; Nagahama, Y.
    Involvement of pH in the enhancement of 20beta-hydroxysteroid dehydrogenase activity in isolated granulosa cell layers from ovarian follicles of salmonid fishes (1990), Biomed. Res., 11, 327-335.
No PubMed abstract available
Search for more literature for 1.1.1.53

Activating Compound

Activating Compound Comment Organism Structure
dibutyryl cAMP only at pH above 7.5 with sufficient Na+ concentration Oncorhynchus mykiss
dibutyryl cAMP only at pH above 7.5 with sufficient Na+ concentration Oncorhynchus masou rhodurus
forskolin only at pH above 7.5 with sufficient Na+ concentration Oncorhynchus mykiss
forskolin only at pH above 7.5 with sufficient Na+ concentration Oncorhynchus masou rhodurus
salmon gonadotropin only at pH above 7.5 with sufficient Na+ concentration Oncorhynchus mykiss
salmon gonadotropin only at pH above 7.5 with sufficient Na+ concentration Oncorhynchus masou rhodurus

Inhibitors

Inhibitors Comment Organism Structure
amiloride Na+/H+-exchanger inhibitor Oncorhynchus masou rhodurus
amiloride Na+/H+-exchanger inhibitor Oncorhynchus mykiss
cycloheximide
-
 Oncorhynchus masou rhodurus
cycloheximide
-
 Oncorhynchus mykiss

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17alpha-hydroxyprogesterone + NADPH + H+ Oncorhynchus mykiss
-
 17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+ maturation-inducing hormone of oocytes ?
17alpha-hydroxyprogesterone + NADPH + H+ Oncorhynchus masou rhodurus
-
 17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+ maturation-inducing hormone of oocytes ?

Organism

Organism UniProt Comment Textmining
Oncorhynchus masou rhodurus
-
 amago salmon
-
Oncorhynchus mykiss
-
 rainbow trout
-

Source Tissue

Source Tissue Comment Organism Textmining
granulosa cell
-
 Oncorhynchus mykiss
-
granulosa cell
-
 Oncorhynchus masou rhodurus
-
ovarian follicle ovarian Oncorhynchus mykiss
-
ovarian follicle ovarian Oncorhynchus masou rhodurus
-
ovary
-
 Oncorhynchus mykiss
-
ovary
-
 Oncorhynchus masou rhodurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxyprogesterone + NADPH + H+
-
 Oncorhynchus mykiss 17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
 ?
17alpha-hydroxyprogesterone + NADPH + H+
-
 Oncorhynchus masou rhodurus 17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
 ?
17alpha-hydroxyprogesterone + NADPH + H+
-
 Oncorhynchus mykiss 17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+ maturation-inducing hormone of oocytes ?
17alpha-hydroxyprogesterone + NADPH + H+
-
 Oncorhynchus masou rhodurus 17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+ maturation-inducing hormone of oocytes ?