Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.53 extracted from

  • Takada, H.; Otagiri, M.; Imamura, Y.
    20beta-Hydroxysteroid dehydrogenase catalyzes ketone-reduction of acetohexamide, an oral antidiabetic drug, in liver microsomes of adult male rats (1998), J. Pharmacol. Exp. Ther., 287, 504-507.
    View publication on PubMed
Search for more literature for 1.1.1.53

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17alpha-hydroxyprogesterone + NADPH + H+ Rattus norvegicus
-
 17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
 ?
progesterone + NADPH Rattus norvegicus
-
 20beta-hydroxy-pregn-4-ene-3-one + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Fischer-344, especially male rats
-

Reaction

Reaction Comment Organism Reaction ID
androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+ exhibits in male rat liver microsomes also a carbonyl reductase-like activity with acetohexamide as substrate Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxyprogesterone + NADPH + H+
-
 Rattus norvegicus 17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
 ?
17alpha-hydroxyprogesterone + NADPH + H+
-
 Rattus norvegicus 17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
 ?
4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide + NADPH male-specific and androgen-dependent activity, competitive to progesterone, cortisone, cortisol and 17alpha-hydroxyprogestrone consumption Rattus norvegicus hydroxyhexamide + NADP+
-
 ?
cortisone + NAD(P)H
-
 Rattus norvegicus 17alpha,20beta,21-trihydroxy-pregn-4-ene-3,11-dione + NAD(P)+
-
 ?
progesterone + NAD(P)H
-
 Rattus norvegicus 20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+
-
 ?
progesterone + NADPH
-
 Rattus norvegicus 20beta-hydroxy-pregn-4-ene-3-one + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus