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Literature summary for 1.1.1.51 extracted from

  • Heyns, W.; de Moor, P.
    A 3(17)beta-hydroxysteroid dehydrogenase in rat erythrocytes. Conversion of 5alpha-dihydrotestosterone into 5alpha-androstane-3beta,17beta-diol and purification of the enzyme by affinity chromatography (1974), Biochim. Biophys. Acta, 358, 1-13.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Dimethylsulfoxide
-
Rattus norvegicus
dioxane
-
Rattus norvegicus
ethanol
-
Rattus norvegicus
glycerol
-
Rattus norvegicus
Propyleneglycol
-
Rattus norvegicus
Triton X-100
-
Rattus norvegicus
Tween-80
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0018
-
NADPH 5alpha-dihydrotestosterone as substrate, 3-beta-hydroxysteroid dehydrogenase activity Rattus norvegicus
0.0021
-
NADPH estrone as substrate, 17beta-hydroxysteroid dehydrogenase activity Rattus norvegicus
0.0082
-
NADP+ testosterone as substrate, 17beta-hydroxysteroid dehydrogenase activity Rattus norvegicus
0.009
-
NADP+ 3beta-hydroxy-5alpha-androstan-17-one as substrate, 3beta-hydroxysteroid dehydrogenase activity Rattus norvegicus
0.14
-
5alpha-dihydrotestosterone
-
Rattus norvegicus
0.31
-
testosterone
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
gel filtration Rattus norvegicus

Organic Solvent Stability

Organic Solvent Comment Organism
dimethylsulfoxide 3.3% v/v: inactivation 43% Rattus norvegicus
dioxane 3.3% v/v: inactivation 90% Rattus norvegicus
Ethanol 1.7% v/v: inactivation 22% Rattus norvegicus
Glycerol 5% v/v: inactivation 26% Rattus norvegicus
propyleneglycol 3.3% v/v: inactivation 50% Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Wistar
-
Rattus norvegicus Wistar
-
Wistar
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta-hydroxy-5alpha-androstan-17-one + NADP+
-
Rattus norvegicus 5alpha-androstane-3,17-dione + NADPH
-
?
5alpha-androstane-3beta,17beta-diol + NADP+
-
Rattus norvegicus 3beta-hydroxy-5alpha-androstan-17-one + NADPH
-
?
5alpha-dihydrotestosterone + NAD(P)H
-
Rattus norvegicus 5alpha-androstane-3beta,17beta-diol + NADP+
-
?
5alpha-dihydrotestosterone + NADP+
-
Rattus norvegicus 5alpha-androstane-3,17-dione + NADPH + H+
-
?
5alpha-dihydrotestosterone + NADP+
-
Rattus norvegicus Wistar 5alpha-androstane-3,17-dione + NADPH + H+
-
?
androst-5-ene-3beta,17beta-diol + NADP+
-
Rattus norvegicus dehydroepiandrosterone + NADPH
-
r
androst-5-ene-3beta,17beta-diol + NADP+
-
Rattus norvegicus Wistar dehydroepiandrosterone + NADPH
-
r
androsterone + NADPH + H+
-
Rattus norvegicus 5alpha-androstane-3alpha,17beta-diol + NADP+
-
?
androsterone + NADPH + H+
-
Rattus norvegicus Wistar 5alpha-androstane-3alpha,17beta-diol + NADP+
-
?
estradiol + NADP+
-
Rattus norvegicus estrone + NADPH
-
r
estradiol + NADP+
-
Rattus norvegicus Wistar estrone + NADPH
-
r
testosterone + NAD(P)+
-
Rattus norvegicus androst-4-en-3,17-dione + NAD(P)H + H+
-
?
testosterone + NAD(P)+
-
Rattus norvegicus Wistar androst-4-en-3,17-dione + NAD(P)H + H+
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 7 reductase activity Rattus norvegicus
8.2
-
dehydrogenase activity Rattus norvegicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
additional information
-
unstable under slightly alkaline conditions Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Rattus norvegicus
NADPH
-
Rattus norvegicus