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Literature summary for 1.1.1.50 extracted from

  • Uwai, K.; Konno, N.; Yasuta, Y.; Takeshita, M.
    Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase (2008), Bioorg. Med. Chem., 16, 1084-1089.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-acetophenone + NADPH
-
Rattus norvegicus 1-phenylethanol + NADP+
-
?
4'-methoxyacetophenone + NADPH + H+
-
Rattus norvegicus 1-(4-methoxyphenyl)ethanol + NADP+
-
?
4'-methoxyacetophenone + NADPH + H+
-
Rattus norvegicus 1-(4-methoxyphenyl)ethanol + NADP+ R,S-enantiomeric product ?
4-bromoacetophenone + NADPH + H+
-
Rattus norvegicus 1-(4-bromophenyl)ethanol + NADP+
-
?
4-cyanoacetophenone + NADPH + H+
-
Rattus norvegicus 1-(4-cyanophenyl)ethanol + NADP+
-
?
4-methylacetophenone + NADPH + H+
-
Rattus norvegicus 1-(4-methylphenyl)ethanol + NADP+ R,S-enantiomeric product ?
4-nitroacetophenone + NADPH + H+
-
Rattus norvegicus 1-(4-nitrophenyl)ethanol + NADP+
-
?
additional information acetophenone derivatives are reduced enantioselectively by rat liver 3alpha-HSD to give (S)-alcohols Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
3alpha-HSD
-
Rattus norvegicus
3alpha-hydroxysteroid dehydrogenase
-
Rattus norvegicus
More cf. EC 1.1.1.213 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus