Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glucose | high glucose level of 25 mM leads to a decrease in G6PD activity and protein level in islets | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MIN-6 cell | - |
Mus musculus | - |
pancreatic islet | high glucose level of 25 mM leads to a decrease in G6PD activity and protein level in islets | Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Mus musculus | high glucose level inhibits G6PD expression | down |
Homo sapiens | high glucose level inhibits G6PD expression | down |
General Information | Comment | Organism |
---|---|---|
metabolism | high glucose level of 25 mM leads to a decrease in G6PD activity and protein level in islets. Inhibition of G6PD with siRNA leads to increase in reactive oxygen species and apoptosis, decreased proliferation, and impaired insulin secretion. High glucose level decreases insulin secretion, which is improved by overexpressing G6PD | Homo sapiens |
physiological function | G6PD-deficient mice have smaller islets and impaired glucose tolerance compared with control mice, which suggests that G6PD deficiency per se leads to beta-cell dysfunction and death | Mus musculus |